At 89, Houston Methodist Dr. Stanley Appel still at forefront of ALS research

When Dr. Stanley Appel established Houston Methodist Hospital’s amyotrophic lateral sclerosis clinic back in 1982, little could be done for patients diagnosed with the progressive nervous system disease. Progress has been incremental in the 40 years that Appel has been focused on treating and researching ALS, also known as Lou Gehrig’s disease, but there have been notable improvements. The multidisciplinary approach at what is now known as Houston Methodist Neurological Institute's MDA ALS Research and Clinical Center is considered a model for ALS treatment. Within the past few years, an immunotherapy treatment developed by Appel and his colleagues has shown promise that it might slow progression of the disease. Now, even at 89 years old, Appel has no plans to stop trying to find a cure. “It's not about your progress. It's about helping people,” Appel said. “And these people are truly inspirational.”

Appel’s four decades of work to advance ALS treatment and research were recognized lst week when he received the Muscular Dystrophy Association’s Tribute Award in Houston. Appel previously served on the MDA Board of Directors from 1979 to 2019 and currently serves as an emeritus board member. “I think persistence has been a key thread, and sticking with a tough assignment,” said Dr. Rodney Howell, a former chairman of the MDA board of directors who has known Appel since 1962. “I think that’s been the hallmark of his success.” The efforts by Appel and other ALS researchers have been buoyed in recent years by an increased focus on the disease. Back in 2014, the Ice Bucket Challenge raised $115 million for the ALS Association. That money was used to fund ALS research, including work by Appel and his colleagues at Houston Methodist. Major League Baseball also lent it support in two years ago when it established Lou Gehrig’s day to raise awareness about the disease that ended the career of the legendary New York Yankees first baseman back in 1939. Appel is taking part in the Houston Astros’ celebration of Lou Gehrig Day during the June 6 game against the Seattle Mariners at Minute Maid Park. He’ll be interviewed on the Houston Astros Radio Network and be featured along with one of his patients, Darci Garcia, in a video that will be played before first pitch.